Apoptosis of nur77/N10-transgenic thymocytes involves the Fas/Fas ligand pathway.

The regulation of apoptosis in thymocytes.

606 The regulation of apoptosis in thymocytes David J. McConkey*$, Mikael Jondalt and Sten Orreniust *Department of Cell Biology, Box 173, The University of Texas, MD Anderson Cancer Center, I 5 I 5 Holcombe Blvd., Houston, TX 77030, U.S.A., +Departments of Microbiology and Tumor Biology, Karolinska Institute, Box 60400, SI040 I Stockholm, Sweden, and $Institute for Environmental Medicine, Divi...

Mitochondrial Pathway Thymocytes Independently of the Glucocorticoid-Induced Apoptosis of Sphingosine Contributes to

Hyperresponse to T-cell receptor signaling and apoptosis of Id1 transgenic thymocytes.

The basic helix-loop-helix transcription factors, E2A and HEB, play important roles in T-cell development at multiple checkpoints. Expression of their inhibitor, Id1, abolishes the function of both transcription factors in a dose-dependent manner. The Id1 transgenic thymus is characterized by an accumulation of CD4- CD8- CD44+ CD25- thymocytes, a dramatic reduction of CD4+ CD8+ thymocytes, and ...

Tumor necrosis factor-related apoptosis-inducing ligand in T cell development: sensitivity of human thymocytes.

TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) is a recently identified member of the tumor necrosis factor cytokine superfamily. TRAIL has been shown to induce apoptosis in various tumor cell lines, whereas most primary cells seem to be resistant. These observations have raised considerable interest in the use of TRAIL in tumor therapy. Yet little is known about the physiologi...

Synergistic Effects of Arsenic Trioxide and Radiation: Triggering the Intrinsic Pathway of Apoptosis

Background: Arsenic trioxide (ATO) has been reported as an effective anti-cancer and a US Food and Drug Administration (FDA) approved drug for treatment of some cancers. The aim of this study is to determine the underlying apoptosis molecular and cellular mechanisms of ATO in the presence or absence of ionizing radiation (IR) in vitro in the glioblastoma multiforme (GBM) cell line, U87MG. Metho...